Protein Details: Neuronal acetylcholine receptor subunit alpha-9
Protein ID
ICDB_Pro_1600
Protein Name
Neuronal acetylcholine receptor subunit alpha-9
Gene Name
CHRNA9
Organism
Gallus gallus (Chicken)
Length
484 amino acids
AlphaFoldDB
AF-Q9PTS8-F1-model_v4.pdb
Function
Ionotropic receptor that may play a role in the modulation of auditory stimuli. Agonist binding induces a conformation change that leads to the opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium; the influx of which may activate a potassium current which hyperpolarizes the cell membrane. .
Sequence
MKRNNLSSFYVSLWLLFTATMLQAVESAKGKYAQMLFNELFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQSWYDAYLKWDKDKYDGLDSIRIPSNLVWRPDIVLYNKADDDFSEPVNTNVVLRYDGKITWDAPAITKSSCVVDVSYFPFDSQQCNLTFGSWTYNGNQVDIINSLDSGDLSDFVEDVEWEIHGMPAVKNVITYGCCSEPYPDVTFTLILKRKSSFYIFNLLLPCILISFLAPLGFYLPADSGEKVSLGVTVLLALTVFQLMVAEIMPPSENVPLIGKYYIATMTMITASTALTIIIMNVHHCGSEAKPVPQWARVVILDYMSKIFFVYDVGENCTSPRREKEQEHRLEGGDMCRGGDGKSHLSSRNDDSDLKENLNGNWNKSFGVHGENVRENVNCCSCYKMLIKNIEYIANCVRDHKANRAKGIEWKKVAKVMDRFFMWIFFIMVFFMSVLIIGKAA
PDB Structures
Ligand Binding
Binding Site
Disease
Location
Expressed in hair cells of the cochlea (at protein level). Expressed in hair cells of the cochlea.
DOI ID
10.1016/s0006-8993(00)01947-8
RefSeq
NP_990091.1;